|Room 4331, 3th building, high-tech industrial park, yizhi road, qingshan district, wuhan, China||Body@bodybiological.com|
|Place of Origin:||Hubei, China|
|Model Number:||CAS: 38304-91-5|
|Minimum Order Quantity:||10gram|
|Packaging Details:||Foil bag|
|Delivery Time:||Within 24 hours|
|Payment Terms:||T/T, Western Union, MoneyGram|
|Shipping Method:||FEDEX, TNT, DHL, UPS, HK EMS||Payment Terms:||Money Gram, Western Union, Bank Transfer|
|Export Market:||USA, UK, France, Thailand, Canana, Brazil||Policy:||Reshipping Policy|
|Function:||Anti Hair Loss||Brand:||Bodybiological|
local anesthetic powder,
anti inflammatory hormone
EP Standard White Raw Powder Positive Anti Hair Loss Minoxidil
Appearance:The product is white or almost white crystalline powder. Dissolved in glacial acetic acid , slightly soluble in ethanol , slightly soluble in chloroform or water , very slightly soluble in acetone.
Minoxidil sulphate was the first drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Before that, minoxidil had been used as vasodilator drug prescribed as oral tablet to treat high blood pressure, with side effects that included hair growth and reversal of male baldness. In the 1980s, UpJohn Corporation came out with a topical solution of 2% minoxidil, called Rogaine, for the specific treatment of androgenetic alopecia. Since the 1990s, numerous generic forms of minoxidil have become available to treat hair loss while the oral form is still used to treat high blood pressure.
The popularity hair loss treatment is due to the general preference in the overall population for the cosmetic appearance of a full head of hair. Minoxidil is used to stimulate hair growth in areas of the scalp that have stopped growing hair. As of early 2001, the exact mechanism of action of minoxidil is not known.
Minoxidil needs to be applied twice daily, and may be used indefinitely for continued support of existing hair follicles and the maintenance of any experienced hair regrowth. To achieve maximum effect, the solution should be in contact with the scalp for at least 4 hours before allowing hair to get wet. Minoxidil stimulates hair follicles and growth, but does not reduce dihydrotestosterone (DHT) or the enzyme responsible for its accumulation around the hair follicle, 5-alpha reductase, which is the primary mediator of male pattern baldness in genetically susceptible individuals. Therefore, when treatment is stopped, the DHT has its expected effect of shrinking and ultimately destroying the genetically predisposed hair follicles. There are multiple types of minoxidil applications: dropper, foam and spray.
Effects on Blood Pressure and Target Organs:
The extent and time-course of blood pressure reduction by Minoxidil do not correspond closely to its concentration in plasma. After an effective single oral dose, blood pressure usually starts to decline within one-half hour, reaches a minimum between 2 and 3 hours and recovers at an arithmetically linear rate of about 30%/day. The total duration of effect is approximately 75 hours. When Minoxidil is administered chronically, once or twice a day, the time required to achieve maximum effect on blood pressure with a given daily dose is inversely related to the size of the dose. Thus, maximum effect is achieved on 10 mg/day within 7 days, on 20 mg/day within 5 days, and on 40 mg/day within 3 days.
The blood pressure response to Minoxidil is linearly related to the logarithm of the dose administered. The slope of this log-linear dose-response relationship is proportional to the extent of hypertension and approaches zero at a supine diastolic blood pressure of approximately 85 mm Hg.
When used in severely hypertensive patients resistant to other therapy, frequently with an accompanying diuretic and beta-blocker, Minoxidil tablets usually decreased the blood pressure and reversed encephalopathy and retinopathy.
Interaction with Guanethidine:
Although Minoxidil does not itself cause orthostatic hypotension, its administration to patients already receiving guanethidine can result in profound orthostatic effects. If at all possible, guanethidine should be discontinued well before Minoxidil is begun. Where this is not possible, Minoxidil therapy should be started in the hospital and the patient should remain institutionalized until severe orthostatic effects are no longer present or the patient has learned to avoid activities that provoke them.
How to use Minoxidil:
Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once or twice a day.
The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight. Your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.
Take this medication and your other blood pressure medications regularly in order to get the most benefit from them. To help you remember, take them at the same time(s) each day. It is important to continue to take your medications even if you feel well. Most people with high blood pressure do not feel sick.
Minoxidil is a clinical oral medication for lowering blood pressure , also known as minoxidil , piperazine pyrimidine diamine, buck fixed , Minoxidil blood given , are potassium channel opener , can direct relaxation of vascular smooth muscle, there is a strong expansion of the role of small arteries , the peripheral resistance decreased , blood vessels expand, blood pressure , and had no effect on the capacitance vessels , it can promote venous return . Meanwhile, the reflex regulation and positive frequency effect, can increase cardiac output and heart rate , but does not cause orthostatic hypotension. Clinic for refractory hypertension and renal hypertension treatment. Can also be used for other antihypertensive drugs ineffective severe hypertension , but the need to avoid sodium retention diuretics can be combined to make increased efficacy , adverse reactions decreased.
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