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|Product Nmae:||MGF||Specification:||2mg/vial 10vials/kit|
|Full Name:||Mechano Growth Factor||Purity:||>99%|
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growth hormone supplements,
hgh human growth hormone
Lab Standard 2MG Mechano Growth Factor MGF Peptide for Muscle Enhancement
What is MGF?
Mechano Growth Factor (MGF) also known as IGF-1Ec is a growth factor/repair factor that is derived from exercised or damaged muscle tissue. It's called MGF as IGF-IEa is a bit of a mouthful and harder to identify amongst the other IGF variants.
What makes MGF special is its' unique role in muscle growth. MGF has the ability to cause wasted tissue to grow and improve by activating muscle stem cells and increasing the upregulation of protein synthesis, this unique ability can rapidly improve recovery and speed up muscle growth. MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-1 receptor domain which, in turn, increases protein synthesis turnover; therefore, if used correctly it can improve muscle mass over time.
MGF differs from the second variant IGF-IEa as it has a different peptide sequence which is responsible for replenishing the satellite cells in skeletal muscle; in other words, it is more anabolic and longer acting than the systematic release of the second MGF liver variant.
So just think of MGF as a highly anabolic variant of igf. After you have trained, the IGF-I gene is spliced towards MGF then that causes hypertrophy and repair of local muscle damage by activating the muscle stem cells as well as other important anabolic processes, including the above mentioned protein synthesis, and increased nitrogen retention.
In rats, some studies have shown muscle mass increases of 20 percent from a single MGF injection, but somehow I think many of these studies are not accurate, however the potential is undeniable.
HOW TO USE MGF?
When you train, what happens to your muscles is they break down, the cells are damaged, muscle tissue needs to be repaired and your body produces 2 forms of MGF splice variant. The first initial release of the above mentioned number 1 variant from the liver helps muscle cell recovery, if there is no MGF then muscle cells die.
As muscle is a post-mitotic tissue and as such cell replacement is not a means of tissue repair, if the cells are not repaired they die and your muscles get smaller and weaker. In muscle tissue, the pool of these stem cells is apparently replenished by the action of MGF, which is produced as a pulse following damage.
Now, with synthetic injections of MGF you can increase the pulse and so speed up recovery, and increase the muscle tissue cells by stimulating satellite cells into full maturity. In terms of dosages, 200mcg bi-laterally is the very best choice of dosing in muscles trained.
The only problem with MGF, and this is the reason I don't like it, is that it has such a short half life, just a few minutes, between 5-7, and it needs to be used immediately post workout as it wont work if muscle tissue hasn’t been damaged. That's why, for me personally, I think the best option is PEG MGF.
Nevertheless, MGF has a huge role to play, and is administered to those with muscle wasting diseases and for those who are elderly and have lost muscle mass for good reason, it is EXTREMELY anabolic.
Mechano growth factor (MGF) is a variation of muscle insulin-like growth factor-1 (IGF-1) triggered by rigorous exercise and muscle damage. Structurally different than other growth factors such as IGF-1 that is synthesized by the liver, MGF enters muscle fibers to repair skeletal muscle tissue and prevent damaged cells from dying off. It adds stem cells into the muscle and is triggered by a pulse of stimulation after muscle tissues undergo significant mechanical stress. Genes for MGF are transcribed to a lesser degree as people age, which is why muscle mass decreases in the elderly, and certain diseases also interfere with the production of it. Supplements do not work as well for older people either because of the decrease in response to mechano growth factor.
The difference between mechano growth factor and IGF-1 is that a group of carbon molecules at the end of the protein, called a C-terminus, controls the release of signals that trigger secretion. When muscles are damaged, MGF is activated, triggers the formation of additional proteins, and enables healthy muscle cell nuclei to form into new tissues and muscle fibers. A more systemic type of insulin-like growth factor from the liver is also produced in higher quantities, aiding in the longer term repair process of muscles.
Injured muscles need to be repaired locally so the damaged cells do not die and lead to further degradation. The release of stem cells regenerates the muscle, and the process is very specific because the contracting elements, energy sources, nuclei, and fluid in the muscle cells, making up the fibers, need to be replenished as well. A lack of growth hormone can lead to deficiencies in mechano growth factor. Hormone replacement therapies, however, can trigger the release of MGH to help the elderly maintain muscle tone and benefit from physical exercise to some degree.
Bodybuilders have tried to inject mechano growth factor directly. Doing this does not have much effect because the substance degrades very quickly. To allow MGF to survive long enough, another substance called polyethylene glycol is injected, which protects the protein structure so that mechano growth factor is activated when weightlifters and other people undergoing rigorous exercise stress their muscles. Polyethylene glycol is used with many pharmaceuticals to deliver drugs to specific areas of the body as well. Used for many purposes, MGF supplements should be used wisely, because only the local area they are injected into will increase in muscle mass, but in a matter of weeks.
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