USP Local Anesthesia Pharmaceuticals Raw Materials Benzocaine HCL
Product name:Benzocain powder
Other name: Ethyl Aminobenzoate
Content: 99% Benzocain powder
Appearance: A white, Crystalline Powder or colorless crystals
Usage:A commonly used topical pain reliever. Main active ingredient in anesthetic ointments.
Benzocaine is an anaesthetic drug, mostly used for application direct to the skin. Benzocaine HCl is a salt modification of benzocaine, formed when benzocaine is complexed with hydrochloric acid. Often, drug salts have enhanced properties compared with the parent compound. For example, benzocaine hydrochloride is more water soluble than benzocaine, making it more appropriate for oral administration.
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform and ethyl ether. The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C. The density of benzocaine is 1.17 g/cm3. Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859–1946), in the town of Eberbach and introduced to the market in 1902 under the name "Anästhesin". Pain is caused by the stimulation of free nerve endings. When the nerve endings are stimulated, sodium enters the neuron, causing depolarization of the nerve and subsequent initiation of an action potential. The action potential is propagated down the nerve toward the central nervous system, which interprets this as pain. Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the nerve membrane, stopping the propagation of the action potential. Over-application of oral anesthetics such as benzocaine can increase the risk of pulmonary aspiration by relaxing the gag-reflex and allowing regurgitated stomach contents or oral secretions to enter the airway. Applying an oral anesthetic and consuming beverages before going to bed can be particularly hazardous. The oral use of benzocaine products has been found to be a cause of methemoglobinemia, a disorder in which the amount of oxygen carried by the blood is greatly reduced. This side effect is most common in children under 2 years of age. Benzocaine may cause allergic reactions. Benzocaine is used as a key ingredient in numerous pharmaceuticals: Over the counter throat lozenges such as Cepacol. Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear. Some previous diet products such as Ayds. Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted. Benzocaine mucoadhesive patches have been used in reducing orthodontic pain. In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
|bp||172 °C (12.7517 mmHg)|
|Stability:||Stable. Combustible. Incompatible with strong oxidizing agents.|
|CAS DataBase Reference||94-09-7(CAS DataBase Reference)|
|NIST Chemistry Reference||Benzoic acid, 4-amino-, ethyl ester(94-09-7)|
|EPA Substance Registry System||Benzoic acid, 4-amino-, ethyl ester(94-09-7)|
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