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CAS 566-48-3 Lentaron Anti Estrogen Steroids Formestane For Breast Cancer
Chemical Designation: 4-Hydroxyandrost-4-ene-3,17-dione
Formula: C 19 H 26 O 3
Molecular Mass: 302.408 g/mol
Active Ingredient: Formestane
Inactive Ingredient: Sodium Chloride
Half-Life: Approx. 30 Hours
Lentaron, a.k.a. formestane, belongs to a class of drugs known as 2 (or second generation) aromatase inhibitors which are primarily used in the treatment of estrogen-receptor positive breast and ovarian cancers in post-menopausal women. Some cancers require estrogen to grow, and aromatase is an enzyme that synthesizes estrogen. Aromatase Inhibitors (AIs) are a class of drugs that effectively block this synthesis thereby lowering estrogenic levels, and slowing the growth of cancers.
Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. Formestane has poor oral bioavailability, and thus must be administered forthnightly (bi-weekly) by intramuscular injection. Some clinical data has suggested that the clinically recommended dose of 250mg was too low. With the discovery of newer, non-steroidal and steroidal, aromatase inhibitors which were orally active and less expensive than formestane, formestane lost popularity. Currently, formestane (categorized as an anti-estrogenic agent) is prohibited from use in sports in accordance to the regulations of the World Anti-Doping Agency. It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn.
Lentaron is available as an intramuscular depot injection, and is often found in 2 ml ampules of 125 mg/ml solution. The recommended dosage for bodybuilder purposes is the same as that for advanced breast cancer therapy, namely 250 mg per week. Formestane can also be found, and taken in the same 250 mg per week dosage in its oral form, but the oral had poor bioavailability is no longer a popular version of this drug.
Lentaron is not widely available as a prescription drug, and is therefore infrequently found within steroid circles. It is very effective when added to anabolic cycles of aromatizing steroids like Dianabol, testosterone (cypionate, propionate, and enanthate), Trenbolone, and Deca-Durabolin.
|Appearance||White crystalline powder|
|Chromatographic purity||Any individual impurity not more than 1.0%
Total impurities not more than 2.0%
|Loss on drying||Not more than 0.5%||0.1%|
|Residue on ignition||Not more than 0.2%||0.1%|
Not detect out
Not detect out
Not detect out
|Assay||Between 97.0% and 102.0%||99.2%|
|Micronixation||90% not more than 10 microns||90% not more than 10 aicrons|
Body Biological Co., Ltd. has been developing and producing high quality products under stric GMP conditions. Quality control and quality assurance are given high priority in order to meet international pharmacopoeia specifications and special customer’s requirements.
1. Method of Analysis for testing our materials are validated to give the re-producible results
2. All the analytical test procedures and manufacturing procedures are well documented and revision is undertaken as per specified protocol.
3. Trend analysis of purified water and final products are maintained.
4. Stability study is a very important area of quality assuance.