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Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7

Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7

    • Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7
    • Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7
    • Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7
    • Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7
  • Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7

    Product Details:

    Place of Origin: Hubei, China
    Brand Name: Bodybiological
    Certification: ISO9001, SGS
    Model Number: 9067-32-7

    Payment & Shipping Terms:

    Minimum Order Quantity: 10gram
    Price: USD1.2/gram
    Packaging Details: Foil bag
    Delivery Time: within 24 hours after the payment
    Payment Terms: T/T, Western Union, MoneyGram
    Supply Ability: 130kg/month
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    Detailed Product Description
    Keywords: Sodium Hyaluronate Alias: Hyaluronic Acid
    Appearance: White Powder CAS: 9067-32-7
    Shipping Method: Fedex, TNT, DHL, UPS, HK EMS Payment Terms: Money Gram, Western Union, Bank Transfer
    Export Market: USA, UK, Brazil, Thailand, France Policy: Reshipping Policy
    MOQ: 10gram Brand: Bodybiological

    Pharmaceuticals Raw Materials Sodium Hyaluronate Hyaluronic Acid for Anti-Wrinkle

     

    whatsapp:+8613429837396

     

    Quick Detail:

     

    Sodium hyaluronate (CAS No.: 9067-32-7) is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective, epithelial, and neural tissues. Sodium hyaluronate, a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine, occurs naturally on the corneal endothelium, bound to specific receptors for which it has a high affinity. The polyanionic form, commonly referred to as hyaluronan, is a visco-elastic polymer normally found in the aqueous and vitreous humour.


    Sodium hyaluronate
    CAS No.: 9067-32-7
    Molecular: (C14H20NO11Na)n
    Synonyms: Hyaluronic acid sodium salt

     

    COA:

     


    ITEMS


    SPECIFICATIONS


    CHARACTERS


    WHITE OR ALMOST WHITE POWDER


    SODIUM HYALURONATE (DRY BASIS)


    ≥90.0%


    GLUCURONIC ACID


    ≥42.0%


    PH(0.1% SOLUTION)


    6.0-7.5


    MOLECULAR WEIGHT


    ≥0.8×106DA

     

    Applications:

     

    Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer of disaccharide units of Na-glucuronate-N-acetylglucosamine. It can bind to specific receptors for which it has a high affinity.
    The polyanionic form, commonly referred to as hyaluronan, is a visco-elastic polymer found in the aqueous and vitreous humour of the eye and in the fluid of articulating joints.

     

    Sodium hyaluronate functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues. It forms a viscoelastic solution in water. Mechanical protection for tissues (iris, retina) and cell layers (corneal, endothelium, and epithelium) are provided by the high viscosity of the solution. Elasticity of the solution assists in absorbing mechanical stress and providing a protective buffer for tissues. In facilitating wound healing, it is thought that it acts as a protective transport vehicle, taking peptide growth factors and other structural proteins to a site of action. It is then enzymatically degraded and active proteins are released to promote tissue repair.

     

    Medical Uses:

     

    It is used to treat knee pain in patients with osteoarthritis who have not received relief from other treatments. It is injected into the joint capsule, to act as both a shock absorber and a lubricant for the joint.[3][4][5] Thus sodium hyaluronate is used as a viscosupplement, administered through a series of injections into the knee, increasing the viscosity of the synovial fluid, which helps lubricate, cushion and reduce pain in the joint.[6] It is generally used as a last resort before surgery[7] and provides symptomatic relief, by recovering the viscoelasticity of the articular fluid, and by stimulating new production from synovial fluid.[2] Use of sodium hyaluronate may reduce the need for joint replacement.[8] Injections appear to increase in effectiveness over the course of four weeks, reaching a peak at eight weeks and retaining some effectiveness at six months, with greater benefit for osteoarthritis than oral analgesics.[9] It may also be effective when used with ankle join.

     

    It is used as an aid in ophthalmic surgery acting as aqueous and vitreous humor, e.g. in cataract extraction (intra- and extracapsular), intraocular lens implantation, corneal transplant, glaucoma filtration, and retina attachment surgery and in the treatment of dry eyes.[11] In surgical procedures in the anterior segment of eyeball, instillation of sodium hyaluronate its viscoelasticity enables maintenance of a deep chamber during surgical manipulation since the solution does not flow out of the open anterior chamber, allowing for efficient manipulation with less trauma to the corneal endothelium and other surrounding tissues. Its viscoelasticity also helps to push back the vitreous face and prevent formation of a postoperative flat chamber. In posterior segment surgery, sodium hyaluronate serves as a surgical aid to gently separate, maneuver, and hold tissues. It creates a clear field of vision, facilitating intra-operative and post-operative inspection of the retina and photocoagulation.
    Sodium hyaluronate is also used to coat the bladder lining in treating interstitial cystitis.

     

    Applications:

     

    Sodium hyaluronate is injected to reduce wrinkles on the face. As of 2017, the FDA had approved 13 hyaluronate preparations as so called dermal fillers.[13] They are also used as a filler of lips or in other parts of the body, though not FDA approved. The filling effect is temporary and lasts for about six months or longer in most people.

     

    Topically applied sodium hyaluronate can facilitate the absorption of biomacromolecules, i.e. pharmaceuticals, and function like a nanocarrier.[16] Its effects on skin depend on the hyaluronate formulation and skin health: In barrier-deficient skin it restricted the delivery of biomacromolecules to the stratum corneum and viable epidermis. In normal skin, low-molecular weight hyaluronate (5 kDa) enhanced penetration into the epidermis.


    Transepidermal water loss increased by 55.5% with low-molecular weight, and was reduced by 28% with crosslinked resilient, and by 16% with HMW . The addition to skin creams became popular in the second millennium. Its efficacy against wrinkles has not been tested in clinical trials.
    After instillation into the lung, higher molecular weight hyaluronate appears to persist longer in the lung but if > 215 kD there was poor lung penetration and mucociliary clearance. Hyaluronate could allow access to lymph nodes draining the pulmonary bed.

     

    COA:

     

    Item Standard
    Appearance White powder
    Solubility Soluble in water, practically insoluble in acetone and in anhydrous ethanol.
    Glucuronic Acid Min.44%
    Sodium Hyaluronate Min.91%
    Appearance of Solution A600nm≤ 0.01
    Nucleic Acid A260nm≤ 0.5
    pH 6.0-7.5
    Molecular Weight 1.0-1.5 Million Daltons
    Protein Max.0.1%
    Loss on drying Max.10%
    Residue on Ignition Max.20%
    Chlorides Max.0.5%
    Iron Max.80ppm
    Heavy metal Max.20ppm
    Arsenic Max.2ppm
    Nitrogen 3.0-4.0%
    Bacteria Count Max.10CFU/g
    Molds & Yeast Max.10CFU/g
    Staphylococcus aureus Negative
    Pseudomonas aeruginosa Negative
    Hemolysis Negative
    Viable Hemolytical Streptococci Negative

     

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    Anti Wrinkle Pharmaceuticals Raw Materials Sodium Hyaluronate CAS 9067-32-7

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