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|Keywords:||HMG||Alias:||Human Menopausal Gonadotrophin|
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peptide growth hormone,
research chemicals peptides
Protein Peptide Hormones Women Menotropins HMG in 75iu/vials in White Ice Powder
Pharmaceutical name: HUMAN MENOPAUSAL GONADOTROPHIN
Active Life: Varies by injection method
Average Dose: Men 2-6 i.u. total daily
Water Retention: Rare
Liver Toxic: No
HMG is produced from a sterile preparation of placental glucoprotein urine of post-menopausal women. The hMG is purified by proprietary chromatographic techniques.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Human Menopausal Gonadotropin, also known as hMG, is an injectable fertility drug that contains equal amounts of FSH and LH. They are sold under the brand names of Menopur and Repronex. The LH and FSH in these drugs is derived from the urine of post menopausal women who produce the hormones in excessive amounts. The urine is extracted and purified, and then used to make the injectable medications.
Human Menopausal Gonadotropins are used to induce ovulation in women with several conditions such as PCOS, Endometriosis, our problems with their pituitary gland (the gland that produces LH and FSH). The injections are given as intramuscular injections, or injections directly into the muscle. The doctor can train a woman or her partner to be able to give the injections at home and not in a doctor’s office setting. The actual act of getting used to giving the injections is usually the hardest part of injectable fertility treatments.
Around 80 percent of women who start taking hMG’s will begin to ovulate within three cycles. Around 60 percent of these women will end up pregnant. That is a great success rate, although of course not all of those pregnancies will be carried to term. You should also be aware that the cost of hMG’s is quite high: around $2000-$5000 for each cycle, and you might need up to six cycles. This medication is not always covered by insurance, so make sure you check with your doctor about that. The cost of the medication does not include other treatments that might be required in conjunction with it, such as IVF or IUI treatments.
The two principal gonadotropins are luteinizing hormone (LH) and follicle stimulating hormone (FSH). Both hormones consist of two peptide chains, an alpha chain and a beta chain, linked by Hydrogen bonds and van der Waals forces. LH and FSH share nearly identical alpha chains, while the beta chain provides specificity for receptor interactions.
A third human gonadotropin is human chorionic gonadotropin (hCG), produced by the placenta during pregnancy.
How to work:
Soluble in 1 to 2 ml of sodium chloride injection and muscle injection. 5 days of the start (or cycle) 1, 75 units, 1 times a day. After seven days, according to patients with estrogen levels and follicular development situation of adjusting dosage. If ovarian response, since the second week every seven days to add 75 units, but each time the dose not more than 225 units. Until after the mature follicle to velvet gonadotrophin (HCG) 10000 units, a muscle injection induced ovulation. For 3 weeks after injection ovarian responders, is discontinued.
What's the success rate of HMG?
Up to 85 per cent of women with an ovulation problem will ovulate after using HMG. About 23 per cent of women with clomifene-resistant PCOS conceive while using HMG and about 20 per cent have a live birth.
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Anion-exchange FPLC. (c) Analysis by reducing and non-reducing SDS-PAGE Silver Stained gel.
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