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HGH has even caused cancer in mice.

"The anti-aging industry tells people that these hormones will make you young again, that they'll reverse years of aging. And this is a total ruse," Perls added. "Part of it is that people equate hormones with youth, and so they think, by getting these drugs, they're going to be young again."

The Lothamers are examined by their doctors every three to five months to make sure their hormone levels are balanced. They say any potential risks are worth the transformation they've experienced.

"When we first started this and people knew we were doing this, they were thinking, 'Yeah, those guys are a little weird anyways.' But it's amazing, it's absolutely amazing how many people approach me now … and they say, 'Ed, what is this all about, how do you feel, do you feel good?' They go, 'Well, Ed's still here and he looks fine, so let's give it a shot,'" Ed Lothamer said.

HGH Uses and Abuses

Synthetic human growth hormone was developed in 1985 and approved by the FDA for specific uses in children and adults. In children, HGH injections are approved for treating short stature of unknown cause as well as poor growth due to a number of medical causes, including:
Turner's syndrome, a genetic disorder that affects a girl's development
Prader-Willi syndrome, an uncommon genetic disorder causing poor muscle tone, low levels of sex hormones, and a constant feeling of hunger
Chronic kidney disease
HGH deficiency or insufficiency
Children born small for gestational age

Short bowel syndrome, a condition in which nutrients are not properly absorbed due to severe intestinal disease or the surgical removal of a large portion of the small intestine
HGH deficiency due to rare pituitary tumors or their treatment
Muscle-wasting disease associated with HIV/AIDS

Nevertheless, some people obtain injectable HGH from doctors who prescribe it for off-label purposes (uses for which it was not approved by the FDA) and through Internet pharmacies, anti-aging clinics, and web sites.

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