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What is Clomiphene?
 

Clomifene, also known as clomiphene, is a medication used to treat infertility in women who do not ovulate.[3] This includes those who have polycystic ovary syndrome.[3] Use results in a greater chance of twins.[3] It is taken by mouth once a day.[3]

Common side effects include pelvic pain and hot flashes.[3] Other side effects can include changes in vision, vomiting, trouble sleeping, ovarian cancer, and seizures.[3][4] It is not recommended in people with liver disease or who are pregnant.[4] Clomifene is in the selective estrogen receptor modulator (SERM) family of medication.[5] It works by causing the release of GnRH by the hypothalamus, and subsequently gonadotropin from the anterior pituitary.[4]

Clomifene was approved for medical use in the United States in 1967.[3] It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[6] It is available as a generic medication.

Clomifene is one of several alternatives for ovulation induction in those who are infertile due to anovulation or oligoovulation.[10] Evidence is lacking for the use of clomifene in those who are infertile without a known reason.[11] In such cases, studies have observed a clinical pregnancy rate 5.6% per cycle with clomifene treatment vs. 1.3%–4.2% per cycle without treatment.

Proper timing of the drug is important; it should be taken starting on about the fifth day of the cycle, and there should be frequent intercourse.

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The following procedures may be used to monitor induced cycles:

Follicular monitoring with vaginal ultrasound, starting 4–6 days after last pill. Serial transvaginal ultrasound can reveal the size and number of developing follicles. It can also provide presumptive evidence of ovulation such as sudden collapse of the preovulatory follicle, and an increase in fluid volume in the rectouterine pouch. After ovulation, it may reveal signs of luteinization such as loss of clearly defined follicular margins and appearance of internal echoes.
Serum estradiol levels, starting 4–6 days after last pill
Post-coital test 1–3 days before ovulation to check whether there are at least 5 progressive sperm per HPF
Adequacy of LH surge by urine LH surge tests 3 to 4 days after last clomifene pill
Mid-luteal progesterone, with at least 10 ng/ml 7–9 days after ovulation being regarded as adequate.
Repeat dosing: This 5-day treatment course can be repeated every 30 days. The dosage may be increased by 50-mg increments in subsequent cycles until ovulation is achieved.[10] It is not recommended by the manufacturer to use clomifene for more than 6 cycles.[13][14]

It is no longer recommended to perform an ultrasound examination to exclude any significant residual ovarian enlargement before each new treatment cycle.

Other medical uses:

Clomifene has also been used with other assisted reproductive technology to increase success rates of these other modalities.[15]

Clomifene is sometimes used in the treatment of male hypogonadism as an alternative to testosterone replacement therapy.[16] It has been found to increase testosterone levels by 2- to 2.5-times in hypogonadal men.[16]

Clomifene has been used in the treatment of gynecomastia.[17] It has been found to be useful in the treatment of some cases of gynecomastia but it is not as effective as tamoxifen or raloxifene for this indication.[18] It has shown variable results for gynecomastia and hence is not recommended for treatment of the condition.[19]

Adverse effectsThe most common adverse drug reaction associated with the use of clomifene (>10% of people) is reversible ovarian enlargement.[13]

Less common effects (1–10% of people) include visual symptoms (blurred vision, double vision, floaters, eye sensitivity to light, scotomata), headaches, vasomotor flushes (or hot flashes), light sensitivity and pupil constriction, abnormal uterine bleeding and/or abdominal discomfort.[13]

Rare adverse events (<1% of people) include: high blood level of triglycerides, liver inflammation, reversible baldness and/or ovarian hyperstimulation syndrome.[13]

Clomifene can lead to multiple ovulation, hence increasing the chance of twins (10% of births instead of ~1% in the general population) and triplets.

Some studies have suggested that clomifene citrate if used for more than a year may increase the risk of ovarian cancer.[11] This may only be the case in those who have never been and do not become pregnant.[20] Subsequent studies have failed to corroborate those findings.[10][21]

The incidence of fetal and neonatal abnormalities for patients on clomifene for fertility is similar to that seen in the general population. There is no data to suggest a higher rate of congenital anomalies or spontaneous abortions after using this drug.[13]

Compared to letrozole, another drug used for ovarian stimulation, a study found no significant difference in the rate of overall abnormalities, but found that congenital cardiac anomalies was significantly higher in the clomifene group compared to the letrozole group.

How to use Clomiphene Citrate:

Clomiphene must be taken by mouth exactly as directed by your doctor in order to be most effective. It is important to follow your dosing schedule carefully.

Your dosage is based on your medical condition and response to therapy. Do not take it more often or for a longer time than prescribed by your doctor. Long-term treatment with this medication is not recommended and should not be more than 6 cycles.

You may be directed to record your body temperature, perform ovulation tests, and properly time sexual intercourse for best results. Ask your doctor if you have any questions.

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