96827-07-5 Hgh Human Growth Hormone Follistatin / FST 344 10mg Per Box For Big Muscle

Human Growth Hormone Peptide Follistatin / FST 344 10mg per Box for Big Muscle

Quick details:

Appearance : White to off-white crystalline powder or lumps
Specific Optical Rotation (c=0.5,10% HAc) :-50.0~-60.0°
Water Content(Karl Fischer) : ≤5.0%
Acetate Content(by HPLC) : ≤15.0%
Amino Acid Composition : ±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) : ≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins : ≤5EU/mg
Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.

Description:

Follistatin is involved in the development of the embryo. It has inhibitory action on bone morphogenic proteins (BMPs); BMPs induce the ectoderm to become epidermal ectoderm. Inhibition of BMPs allows neuroectoderm to arise from ectoderm, a process which eventually forms the neural plate. Other inhibitors involved in this process are noggin and chordin.

Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.

Application:

Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an Nterminal atypical TGF binding domain, three Follistatin domains that contain EGFlike and kazallike motifs, and a highly acidic Cterminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2, -4, -6, -7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids .

Does Follistatin Build Muscle?

In short, follistatin does build muscle but not necessarily in humans. A number of studies support the muscle-building and anti-degenerative effects follistatin in rodents. Unfortunately there is no formal research examining follistatin usage in human subjects but a quick Google search will yield countless amateur follistatin logs on bodybuilding and fitness forums.
When scientists bred a mouse producing no myostatin and extra follistatin it had 117% larger muscle fibers and 73% more total muscle fibers compared to the mice in the control group. [8] This study demonstrates that follistatin positively impacts muscle growth in ways beyond simply suppressing myostatin. Mice with suppressed myostatin had twice the muscle mass but mice with the follistatin transgene and suppressed myostatin had four times as much muscle mass compared to the control group.
Not only do increased follistatin levels correlate to increased muscle mass, but a lack of the follistatin protein at birth directly correlates to less muscle mass. Less muscle mass at birth can negatively impact bone, organ, and tissue development as well as normal hormonal function.
 

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