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Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar

Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar

    • Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar
    • Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar
    • Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar
    • Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar
  • Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar

    Product Details:

    Place of Origin: Hubei, China
    Brand Name: Bodybiological
    Certification: ISO9001, SGS
    Model Number: CAS: 475207-59-1

    Payment & Shipping Terms:

    Minimum Order Quantity: 1gram
    Price: USD1/gram
    Packaging Details: Foil bag
    Delivery Time: Within 24 hours
    Payment Terms: T/T, Western Union, MoneyGram
    Supply Ability: 160kg/month
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    Detailed Product Description
    Keywords: Nexavar Appearance: White Powder
    Shipping Method: EMS, HKEMS, USP, DHL, EUB, FEDEX Payment Terms: Money Gram, Western Union, Bank Transfer
    Delivery Time: 5-7 Days Whatsapp: +8613264710010
    Export Market: USA, UK, Thailand, Brazil, Canada Brand: Bodybiological

    Anti-cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar
     
    Nexavar
    Product Name: Sorafenib tosylate
    CAS Number: 475207-59-1
    Formula: C21H16ClF3N4O3. C7H8SO3
    Molecular Weight: 637.03
    Melting Point:202-204°C
    Storage Temp. -20°C Freezer
    Appearance: Light brown solid powder
    Loss on drying: Less than 0.5%
    Heavy metals: Less than 10ppm
    Total impurities: Less than 1.0%
    Content: 99%
    Usage: Toluenesulfonic Sorafenib is a novel multi-target anticancer drugs, can act simultaneously on tumor cells and tumor blood vessels. It has a dual anti-tumor effects: Either by blocking the RAF / MEK / ERK-mediated cell signaling.

    Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar),[1] is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
    Mechanism of action
    Sorafenib is a small inhibitor of several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases (more avidly C-Raf than B-Raf).
    (See BRAF_(gene)#Sorafenib for details of drug structure interaction with B-Raf.)
    Sorafenib treatment induces autophagy, which may suppress tumor growth. However, autophagy can also cause drug resistance.
     
    Medical uses
    At the current time sorafenib is indicated as a treatment for advanced renal cell carcinoma (RCC), unresectable hepatocellular carcinomas (HCC) and thyroid cancer.
     
    Kidney cancer
    An article in The New England Journal of Medicine, published January 2007, showed that, compared with placebo, treatment with sorafenib prolongs progression-free survival in patients with advanced clear cell renal cell carcinoma in whom previous therapy has failed. The median progression-free survival was 5.5 months in the sorafenib group and 2.8 months in the placebo group (hazard ratio for disease progression in the sorafenib group, 0.44; 95% confidence interval [CI], 0.35 to 0.55; P<0.01).[11] A few reports described patients with stage IV renal cell carcinomas, metastasized to the brain, that were successfully treated with a multimodal approach including neurosurgical, radiation, and sorafenib.[12] This is one of two TGA-labelled indications for sorafenib, although it is not listed on the British Pharmaceutical Benefits Scheme for this indication.
     
    Liver cancer
    At ASCO 2007, results from the SHARP trial were presented, which showed efficacy of sorafenib in hepatocellular carcinoma. The primary endpoint was median overall survival, which showed a 44% improvement in patients who received sorafenib compared to placebo (hazard ratio 0.69; 95% CI, 0.55 to 0.87; p=0.0001). Both median survival and time to progression showed 3-month improvements. There was no difference in quality of life measures, possibly attributable to toxicity of sorafenib or symptoms related to underlying progression of liver disease. Of note, this trial only included patients with Child-Pugh Class A (i.e. mildest) cirrhosis. The results of the study appear in the July 24, 2008, edition of The New England Journal of Medicine. Because of this trial Sorafenib obtained FDA approval for the treatment of advanced hepatocellular carcinoma in November 2007.
     
    In a randomized, double-blind, phase II trial combining sorafenib with doxorubicin, the median time to progression was not significantly delayed compared with doxorubicin alone in patients with advanced hepatocellular carcinoma. Median durations of overall survival and progression-free survival were significantly longer in patients receiving sorafenib plus doxorubicin than in those receiving doxorubicin alone.[4] A prospective single-centre phase II study which included the patients with unresectable hepatocellular carcinoma (HCC)concluding that the combination of sorafenib and DEB-TACE in patients with unresectable HCC is well tolerated and safe, with most toxicities related to sorafenib.[15] This is the only indication for which sorafenib is listed on the PBS and hence the only Government-subsidised indication for sorafenib in Australia. Along with renal cell carcinoma, hepatocellular carcinoma is one of the TGA-labelled indications for sorafenib.
     
    Thyroid cancer
    A phase 3 clinical trial has started recruiting (November 2009) to use sorafenib for non-responsive thyroid cancer.[16] The results were presented at the ASCO 13th Annual Meeting and are the base for FDA approval. The Sorafenib in locally advanced or metastatic patients with radioactive iodine-refractory differentiated thyroid cancer: The Phase 3 DECISION trial showed significant improvement in progression-free survival but not in overall survival. However, as is known, the side effects were very frequent, specially hand and foot skin reaction.
     
    Desmoid tumors
    A phase 3 clinical trial is under way testing the effectiveness of Sorafenib to treat desmoid tumors (also known as aggressive fibromatosis), after positive results in the first two trial stages. Dosage is typically half of that applied for malignant cancers (400mg vs 800mg). NCI are sponsoring this trial.
     
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    High quality product All of our product is manufactured by ourselves, high quality could be guaranteed.
    Discreet packing methods For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels.
    99.99% customs clearance rate We have rich experience in shipping parcel to all over the world. We have the special channel for some special countries.
    Injectable steroid We offer cooking powder into liquid service.And ship the liquid in special bottles.
    Label and vials customize We can offer label and vials customize to creat your own brand.
    Faithful service Best service with after-sales service to all clients.

     
    Anti cancer Sorafenib Tosylate Pharma Raw Material Pharmaceutical Nexavar

    Contact Details
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    Contact Person: Viki

    Tel: +8613264710010

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